Methods. Rich on haematological and biochemical parameters in healthy Wistar rats. 2007;39(1):4484. Justicia carnea has been used in traditional medicine to treat diabetes. 200, 500 and 1000 mg/kg bw of Justicia carnea showed a significant (p<0.05) decrease in the activities of ALT, AST and ALP, and bilirubin level while total protein and albumin levels increased significantly (p<0.05) when compared with the rats treated with CCl alone. Liver and kidney are the main targets of toxicants because they are respectively involved in biotransformation and excretion of xenobiotics. Justicia Carnea leaves extract contains a rich supply of iron, riboflavin, vitamins A, C, E, B1, B2, B9, and B12. 2015;174:61827 https://doi.org/10.1016/j.jep.2015.06.005. The plant produces dark green leaves around 8 inches in length. View abstract. Evid Based Complement Alternat Med. The shrubby habit of the plant is well-suited for both containers and outside planting. Radhika J, Sathya S, Jothi G, Japasheba JL. J Ethnopharmacol. Nutritive properties of aqueous extract Justicia carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male wistar albino rats. Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats. aqueous extract J. carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male Wistar albino rats. The changing faces of glutathione, a cellular protagonist. Total reaction mixture of 3ml contained 2.95ml of 0.05M sodium carbonate buffer (pH10.2), 0.02ml tissue sample and 0.03ml of epinephrine (2mM) in 0.005N HCl was used to initiate the reaction. In subacute study, rats were randomized into six groups of five rats per group: Group 1 (control) received distilled water, group 2, 3, 4, 5, 6 received 50, 100, 500, 800 and 1200mg/kg body weight of J. carnea ethanol extract once daily using oral gavage. Walters DM., Cho Hye-Youn, Kleeberger SR. Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2. Keep the soil moist, but not waterlogged. Relative to the control, liver of rats treated with doses of J. carnea ethanol extract showed varied degree of hepatic injury in a dose dependent manner. Also, remove old flowers to keep the plant healthy. You can add milk or honey for taste before drinking. The present study investigated the antioxidant and in vitro antidiabetic capacities of Justicia carnea aqueous leaf extract (JCAE) using -amylase inhibition model. The plant, which is usually green in color and produces pink flowers, belongs to the family of Acanthaceae. Powdered sample (1000g) was soaked in absolute ethanol (3000mL) with constant stirring. Chariandy, C. M., Seaforth, C. E., Phelps, R. H., Pollard, G. V., and Khambay, B. P. Screening of medicinal plants from Trinidad and Tobago for antimicrobial and insecticidal properties. Toxicity studies of medicinal plants used in sub-Saharan Africa. 3. The present study investigated the antioxidant and in vitro antidiabetic capacities of Justicia carnea aqueous leaf extract (JCAE) using -amylase inhibition model. Justicia Carnea; Blood-Boosting Green Plant That Turns Hot Water Red! Oyenihi OR, Brooks NL, Oguntibeju OO. However, coadministration of both extracts exerts a synergistic effecton the . Brazilian-plumeflowers are best propagated from softwood cuttings. Another plant with this benefit is fertility tree. Justicia carnea (Brazilian Plume) - Gardenia.net There is however little publications available on the pharmacological properties of the herbal plant. 2015;15:236. https://doi.org/10.1186/s12906-015-0760-y. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. This information may not fit your specific health circumstances. Mr. T.S. For a few weeks, the cutting should be watered every day to promote root development. Studies on The Phytochemical and Nutritional Composition of Aqueous Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. (2020). Oral acute toxicity study on J. carnea ethanol extract (JCEE) was carried out according to Lorke [15] method using the total of twelve (12) albino rats in two phases. Hepatic and renal damage has been recently linked with the use of medicinal plants in the treatment of various diseases [5, 6]. If you provide us with your name, email address and the payment of a modest $25 annual membership fee, you will become a full member, enabling you to design and save up to 25 of your garden design ideas. PubMed All rights reserved. Prevent this by spraying the leaves with water. Eyong EU, Umoh IB, Ebong PE, Eteng MU, Antai AB, Akpa AO. Anaemia is a common blood disorder that affects people of all ages, though people at greater risk are the elderly, young women and infants. Ewe eje is mainly given to persons who want a blood boost such as pregnant women, persons suffering from anemia and other convalescents. Note this is the default cart. Justicia Carnea is a flowering plant that may be found in our neighborhood. Niger J Physiol Sci. Justicia carnea and Cnidoscolus aconitifolius were tested for their capacity to ameliorate the fecundity of chloramphenicol-induced lymphoma in rats. Hepatoprotective Effect of Methanol Extract of Justicia carnea Leaves long (20 cm), densely packed with pink to crimson tubular flowers. Nigeria's medicinal plant: Justicia carne (Ewe eje) Inter J Pharm Sci Res. Sedlak J, Lindsay RH. Ewe eje improves the production of white blood cells and other antibodies, all which are essential for strengthening immunity. At the end of the 14th day of administration, the rats were allowed to fast overnight and sacrificed the following morning by anesthetizing each rat in a closed chamber containing drops of chloroform. Ogwu obara can act as a blood tonic for women during menstruation. 50mg/kg-1200mg/kg treatment relative to control treatment showed varied degree of renal injury that is dose dependent. In these groups, from mild to severe order; shows observable congested portal vein, the liver parenchyma showed area of harmorrhage, the morphology of the hepatocytes appear pyknotic, some show mild fat infiltration (red arrow) the sinusoids appear fibrotic with infiltration of inflammatory red cells (red arrow). 2011;5(9):48992 https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867. This study has confirmed the safety of ethanol extract of J. carnea leaf and validates its conventional use as blood booster. Provided by the Springer Nature SharedIt content-sharing initiative. Create a beautiful garden with this colorful and Use our interactive toolsto design your dream garden. Consequently, the effects of the extract on MDA level could indicate damage to cell membrane lipids of the hepatocyte which could result to increased generation of reactive oxygen species (ROS). Justicia carnea belongs to the family- Acanthaceae. This plant is somewhat drought-tolerant once established but looks best with regular watering during periods of extended dry weather. This is why you should avoid potting them if you live in colder areas. A cup of water Note: A=change in absorbance, TV=total volume, SV=sample volume, TP=total protein, =molar extinction =1.34104M1 cm1. Treatments of experimental animals were in accordance with the Principle of Laboratory Animal Care manual guide of National Institute of Health [14] as approved by the Institution Research Ethics committee. Justicia carnea needs bright, indirect light to thrive. Aside boosting blood production in normal persons, justicia carnea leaves also reverses anemic conditions. The resultant liquid would turn crimson red. Liver superoxide dismutase (SOD) activity was significantly (p<0.05) increased at 1200mg/kg while other tested doses caused no detrimental effect on glutathione, catalase, SOD and malondialdehyde level in liver and kidney. Rats were routinely observed for signs of toxicity. According to acute toxicity grading standards, LD50 of substances greater than 5000mg/kg is practically considered non-toxic [22, 23]. ESA conceived and designed the study. From mild to severe order, the graded doses showed distorted renal cortex with collapsed renal glomeruli and dillated capsular spaces. Cookies policy. Ethanol extracts of J. carnea leaf increased RBC, hemoglobin and platelet with significant increase (p<0.05) in groups that received higher dose (>500mg/kg b.w) of extract compared to the control. Due to the local availability, easy access and relatively low cost, medicinal plants are gaining attentions in health care programmes. Background: Justicia carnea is a medicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. Canadian J Appl Sci. This is due to the inability of the pancreatic beta cells to secrete insulin, which transports glucose to cells, or the inability of cells of the body to recognize insulin. Research reports it isn't capable of . Article The findings back up local assertions that they can be. In-vitro Antioxidant Screening of Ethanol Extracts of Costus afer and This lends the plant some interesting names such as Blood of Jesus plant and Hospital too far. There are several claims that justicia carnea can prevent epilepsy and convulsion among children. [1] The perennial plant is native to the Atlantic Forest ecoregions of eastern Brazil . When properly boiled in water, the aqueous leaf extract turns red, and when mixed with milk turns pink. Based on estimation by World Health Organization (WHO), larger percentage (between 80 and 90%) of the worlds population especially in developing countries depends on traditional system of medicine [1, 2]. In this report, MCV, MCH and MCHC in treated group were not altered compared to the control. The acute toxicity test also proved that justicia carnea leaves are safe for consumption. Kone WM, Koffi AG, Bomisso EL, Tra Bi FH. The aim of this study is to evaluate the effects of J. carnea leaf extract on hematology indices and organ antioxidant system in healthy wistar rats. Haematoxic effects following ingestion of Nigerian crude oil and crude oil polluted shellfish by rats. During the growing season, the justicia (plant) should be watered thoroughly with room temperature water. To use the website as intended please Studies on The Phytochemical and Nutritional Daily intake of the Ewe eje or ajeri can increase the absorption of iron and vitamins, Uses and health benefits of Ewe eje (Justicia carnea leaf). The possible anti-anaemic property of the leaf could be linked to the improved hemoglobin, PCV and RBC observed in this study. Rats were further observed for extended hours of 48h to see if mortality would occur. https://doi.org/10.1016/j.jep.2005.06.013. Faiza R, Waqas KK, Adeel M, Muhammad G. Detection of bioactive fractions of Justicia adhatoda leaves. Tissues were stained with haematoxylin and eosin, mounted on glass slides and examined under a standard light microscope. In the kidney, SOD and MDA level were indistinguishable compared to the control except SOD level in rats that received 800mg/kg JCEE that reduced significantly (p<0.05). Chemical constituents and biological activities of species of Justicia a review. This later condition is termed insulin resistance. J Ethnopharmacol. degree in Biochemistry from Olabisi Onabanjo University, Ago-iwoye, and University of Ibadan, Ibadan, Nigeria respectively. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. Mapanga RF, Musabayane CT. National Research Council. While the renal tubules across the tested groups were normal with the interstitial spaces showing moderate congestion and hemorrhage, there appeared some abnormalities in the renal cortex (such as few sclerotic glomeruli with moderately dilated capsular spaces) resulting in fair architectural structure of the kidney (Fig. JUSTICIA PECTORALIS - Uses, Side Effects, and More - WebMD As reported by science, Justicia carnea is composed of secondary metabolites such as: flavonoids, terpenoids, alkaloids, phenols, saponins and tannins. 5. Justicia carnea is a popular ornamental plant, which possesses powerful medicinal values. The non significant decrease observed in this study is in consonance with the work of Onyeabo et al., [9] who also reported no significant difference in the relative weights of liver and kidney. J Med Plants Res. It is very rich in iron, a major component is RBC hemoglobin. Justicia carnea [jus-TEE-see-ah, KAR-nee-uh] is popularly known as the Brazilian Plume Flower. This study investigated the in-vitro antioxidant activity of ethanol leaf extract of Justicia carnea and its effect on antioxidant status of alloxan-induced diabetic albino rats. Mukinda JT, Syce JA. They protect our cells from the harmful effects of reactive oxygen species. SOD activity was determined by its ability to inhibit the auto-oxidation of epinephrine determined by the increase in absorbance at 480nm. PubMed Central The levels of white blood cell count, lymphocyte, granulocyte and MID could indicate that ethanol extract of J. carnea leaf pose no toxicity or sub acute inflammation to the overall defense mechanism and immunity of the experimental rats. Briefly, 1.0ml of the sample was mixed with 2ml of TCA-TBA-HCl reagent (0.37% thiobarbituric acid, 15% trichloroacetic acid and 0.24N HCl in 1:1:1) and boiled at 100C in a water bath for 15min. It is a creeping, perennial plant and grows up to 2 meters tall. The description of these plants has been written based on numerous outside resources. A., Bezerra, G. A., Matos, F. J., and Viana, G. S. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. Paradoxically, oxidation of GSH has been reported to occur when GSH interact with metal ions thereby generating superoxide anions from the transfer of electrons from the metal ions to molecular oxygen [32]. The absorbance of the supernatant was measured against reagent blank at 532nm. Grows up to 4-6 ft. tall (120-180 cm) and 2-3 ft. wide (60-90 cm). They range in colors such as red, orange, mauve, magenta, apricot, and pink. Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies. Ewe eje or Ewe ajeri is known by the Igbo tribe as Ogwu obara. CAS Philadelphia: WB. Justicia Carnea Leaf Benefits - Ewe eje - besthomediet It also increases good cholesterol levels. J. Appl. Google Scholar. Oso BJ, Oyewo EB and Oladiji AT. Google Scholar. Sample (or standard solution) (0.01ml) was mixed with diluted (1:4v/v distilled water) biuret reagent (100mM sodium hydroxide, 16mM sodium-potassium tartrate, 15mM potassium iodide and 6mM copper sulphate). Mr. E.S. In an acute exposure of experimental rats to single oral doses of extract, no mortality and signs of adverse effects were observed. Justicia pectoralis seems to have antibacterial and anti-inflammatory effects. Each rat was dissected and blood samples were collected by cardiac puncture using 5mL into tubes containing ethylenediaminetetraacetic acid (EDTA) for hematological analysis. 2010;4(8):6804 https://doi.org/10.5897/JMPR09.487. This suggested that the extract did not alter tissue function in converting harmful hydrogen peroxide to water and oxygen. 8-10 Justicia carnea leaves. Phytochemical profile, antioxidant, -amylase inhibition, binding Lorke D. A new approach to practical acute toxicity testing. Although, medically, it is advised you see your doctor or a physician before using the leaf for medicinal uses. This is . Ewe eje can increase blood count and volume. J Ethnopharmacol 2000;70(2):151-159. Ewe eje can also be used to manage abnormalities associated with anaemia and for the treatment and management of diabetics. It is nicknamed the Blood leaf, Blood of Jesus, and Jehovah Witness leaf in Nigeria, and is a widely used leaf across states in Nigeria. Ewe eje isn't capable of causing any side or negative effects if consumed moderately. volume7, Articlenumber:2 (2021) We currently have no information for JUSTICIA PECTORALIS overview. 2003;66:1499503. Two of the most important soil considerations include fertility and drainage. Rats in the 3 different groups received 10, 100 and 1000mg/kg body weight of JCEE orally using oral gavage. Olumese FE, Onoagbe IO, Eze GI, Omoruyi FO. Inhibitory Potential and Antidiabetic Activity of Leaf Extracts of Justicia carnea. In various parts of Africa, several species of Justicia are used in traditional medicine for the treatment of anemia, inflammation, fever, diarrhea, liver diseases and arthritis respiratory and gastrointestinal disorder [8, 9]. Becoming a contributing member of Gardenia is easy and can be done in just a few minutes. The findings show that ethanol extracts of Costus afer and Justicia carnea could operate as main antioxidants and free radical scavengers. View abstract. Rich, well-drained soil retaining ample moisture is the perfect home for Brazilian plume flowers. PDF Effects of Ethanol Leaf Extract of Justicia Carnea on Biochemical This could possibly indicate SOD stimulating effects of J. carnea leaf ethanol extract. Aim. The botanical name- Justicia carnea was coined after a scotish- James Justice, who happens to have found the plant first. The result from the kidney histology could be due to the presence of active secondary metabolites and daily dosing of the extract. Manage cookies/Do not sell my data we use in the preference centre. View abstract. Beijing: Chemical Press; 2011. In a pot, pour in a cup of water and bring to a boil. Different drugs are used but many depend mainly on plants and herbal products for its treatment. The reference cuvette contained 2.95ml buffer, 0.03ml of substrate (epinephrine) and 0.02ml of water. van Andel T., Carvalheiro LG. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. BMC Complem Altern Med. 2007;112(1):13844. leaf inhibits interferon-γ secretion and has bacteriostatic activity against Acinetobacter baumannii and Klebsiella pneumoniae. 1978;52:30210. 2015;6(7):265270. This is in agreement with previous work on the reversed effect of J. carnea leaf extract on anaemia induced experimental rat [9, 21]. The plant possess several bioactive compounds like polyphenols, which act as antioxidants or anti-inflammatory compounds. statement and All analyzed dataset to support the conclusions of this article is included as tables in the uploaded supplementary files. It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. Anaemia is a common blood disorder that affects people of all ages, though people at greater risk are the elderly, young women and infants. Stover PJ, Caudill MA. Generic and epigenetic contributions to human nutrition and health: managing genome-diet interactions. Generally disease free. Higher doses (>500mg/kg) of extract significantly (p<0.05) increased RBC, hemoglobin and platelet compared to the control. Acute and sub-acute toxicity studies of aqueous and methanol extracts of Nelsonia campestris in rats. Make sure to follow the package instructions carefully. Safety assessment of oral administration of ethanol extract of, $$ \mathrm{Total}\ \mathrm{protein}\kern0.5em =\kern0.5em \frac{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{sample}}{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{standard}}\kern0.5em \times \kern0.5em \mathrm{Concentration}\ \mathrm{of}\ \mathrm{standard} $$, $$ \mathrm{Catalase}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}\right)=\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{SOD}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}/\mathrm{mg}\ \mathrm{protein}\right)\kern0.5em =\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{Concentration}\kern0.5em \mathrm{of}\kern0.5em \mathrm{reduced}\kern0.5em \mathrm{GSH}\kern0.5em =\kern0.5em \frac{\left(\Delta \mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\left(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}\right)} $$, $$ \mathrm{Malondialdehyde}\kern0.5em =\kern0.5em \frac{\left(\mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\Big(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, https://doi.org/10.1186/s40816-020-00234-4, https://doi.org/10.1016/j.jep.2015.06.005, https://doi.org/10.1016/j.joad.2015.08.006, https://doi.org/10.1016/j.jep.2005.06.013, https://doi.org/10.3109/08860220903367585, https://doi.org/10.1590/S0102-695X2011005000196, https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867, https://doi.org/10.35841/biomedicalresearch.30-18-666, https://doi.org/10.1016/j.jep.2007.02.011, https://doi.org/10.1186/s40816-019-0104-4, https://doi.org/10.1016/j.fitote.2008.02.005, https://doi.org/10.1016/j.jada.2008.06.430, https://doi.org/10.1016/j.biocel.2006.07.001, https://doi.org/10.1186/s12906-015-0760-y, http://creativecommons.org/licenses/by/4.0/.