A great packaging session when youre making blisters requires patience, right calculation and technical help. 0000006698 00000 n On the other hand, the blister cavity must remain accessible by the push-through effect and the formed web may not be too hard to collapse when pressed upon; for this reason the PVC sheet thickness is typically chosen between 200 to 300 depending on the cavity size and shape. Knurls are the patterns on the lidding foil and the slots made on the packaging material for holding the tablets. By contrast, the fragility and larger pocket size of CFF (Cold Formed Foil) blisters means they are better suited to platen sealing. 0000048162 00000 n This article describes the main types, categorized as follows: Strip Packing Machine High Speed Tablet Strip Packing Machine Automatic/Soft Double Al Strip Packing Machine Strip size: Measure the length and width of strip and verify the results with the values given in packaging technical directions. The principal disadvantages of cold form foil blisters are: the slower speed of production compared to thermoforming; the lack of transparency of the package (a therapy compliance disadvantage); and the larger size of the blister card (aluminum can not be formed with near 90-degree angles). Copyright 2021 Sepha. It can be used as a security package to deter package pilferage for small high-value items, such as consumer electronics. The tool holder measures 5/16 wide x 3/4 tall. PVDC grades are available in 2 types of polymer: (I) the historic grades offering medium to high barrier properties and (II) a super barrier coating grade offering the highest barrier. Brief Description of Blister Pack - Jornen Even with an apparently great sealing session, there are tiny spaces known as micro channels that are caused through the seal, through which moisture can reach the product and decrease quality and shelf life. In order to be suitable for pharmaceutical blister packs, the PVC formulation also needs to comply with the US Pharmacopoeia <661>; EU food legislation; US 21.CFR and Japanese food contact requirements. By far the most common and inexpensive destructive blister leakage test is the vacuum test using methylene blue. This makes choosing a blank diameter easier. Some popular knurl patterns are straight, diagonal, and diamond. Camera-based integrity testing offers pharmaceutical packaging operations increased efficiencies by utilising non-destructive techniques as part of theprocess. The most basic material for the forming web is polyvinyl chloride (PVC). Cold form foil film (or cold-formed foil)[8] is made of a 3-layer laminate: PVC/Aluminum/Polyamide. Standard, also known as straight, knurl wheels are used to create a straight knurl pattern. The Different Types of Tablet Packing Machines A wide variety of tablet packaging machines are available from different manufacturers. Let us do your packaging for you. Blister pack - Wikipedia Blister pack is a general term that describes packaging that uses a process known as thermoforming. End-Rolling Knurlers are used for entering a workpiece axially. The product label needs to include a statement similar to the following: "Do not use if blister is cut or broken". PCTFE films have the lowest water vapor permeation compared to all other plastic films used in blister packaging and have thermoforming properties similar to plain PVC though it is also the most expensive. Blister packs are commonly used as unit-dose packaging for pharmaceutical tablets, capsules or lozenges. 8 Top Tips for achieving a Brilliant Blister Seal, Founded in 1980, Sepha has established a global reputation for innovation and development of specialised, high-quality equipment for use in the manufacture of pharmaceutical blister packs, parenterals, medical devices and healthcare products. This wheel is made from cobalt which is harder than high speed steel and provides excellent wear resistance. any external factors that can adversely affect/alter properties. Blister pack is a term for several types of pre-formed plastic packaging used for small consumer goods, foods, and for pharmaceuticals. The heat seal areas of the material shall also be kept in check and it shall be glossy, clear of grime and resistant to abrasion. They are used at higher speeds than bump knurlers. The lidding foil is coated with a heat-seal lacquer on the inside and a print primer on the outside. 1 What is importance of knurling in blister packing. Use smaller knurls on a narrow web, since the air can escape more easily. 0000146626 00000 n All thermo-forming machinery operators must know that the material used in blistering can have an effect on the drug. Mock clamshells are often half the price of regular clamshells. This allows for a complete view of the product while providing plenty of eye-catching marketing real estate on the paperboard card. Rotary sealing machines are a great choice for long blistering sessions but even they need regular maintenance. 0000003079 00000 n With the plastic blister sealed between two cards, trapped blisters are more tamper-resistant than face seal blister packages being sealed to the front of a coated card. Please enter valid partnumber and quantity. For best results, you may want to vary the type of knurl depending on the type of lidding you run. PDF Annex 9 Guidelines on packaging for pharmaceutical products As mentioned above, there are a wide variety of knurling applications. Knurling can produce different types of patterns. Most pharmaceutical companies around the world rely on blister packs to guarantee theuniformity, purity, integrity, safety and stability of their products. This lip is there to enforce the edges and protect the blister card (where all your awesome graphics are printed) from being damaged from potentially rough handling by customers or store workers. In the 1960s, blister packaging commenced its key journey of delivering medications. 8 Blister Sealing tips for achieving a perfect blister seal | Sepha How to Buy Packaging 101 Part 2 Determining Your Packaging Needs. gp([t&&jE&R-Hg:'}! The device has a component of a bubble pack that may be a cavity or pocket made up of a formable film, usually a thermoformed plastic or cold-formed aluminum film. : Ensure that your workpiece is concentric and make sure the knurling wheel is set on the centerline. The Different Types of Tablet Packing Machines - LFA Tablet Presses Blister packs can provide barrier protection for shelf life requirements, and a degree of tamper resistance. The primary component of a blister pack is a cavity or pocket made from a formable web, usually a thermoformed plastic. Demand for PCR content in packaging far exceeds available supply, but emerging technologies could help increase production. This is made possible as the knurling wheels can be switched in and out. Convex knurls on the other hand have a sharp leading edge to provide a very smooth and precise finish. These vary in sensitivity, technology and cost, and include blue dye, helium trace gas, force decay and laser/vision deflection. This usually has a backing of paperboard or a lidding seal of aluminum foil or plastic. Heat and sometimes vacuum is applied in order to adhere the film tightly onto the product and card. Single-Seal Blister Card Available in a variety of seal types, a single-seal is coated and heat-sealed to a thermoformed blister part. PDF World Journal of Pharmaceutical Research et al. World Journal of Each material combination requires specific dwell time, pressure and temperature settings to achieve the optimum seal. Tooling costs are more expensive for clamshells than the aforementioned blister styles. They commonly have a 30 left hand helix angle. From safety precautions to single or double wheel knurling and knurling best practices, you can dive much deeper and continue your knurling research here. Required fields are marked *. 0000021700 00000 n Concerning pharma packaging, the material being used is as important a factor as the compounds being used in the production of the pill or capsule. "q(v>dj`js1y/Q(*(RY Customers get a full 360 view of the product. endstream endobj startxref Packing is mainly of three types. Wrong pressure might either harm the main PVC film or cause the sealing foil to detach even after the heat sealing is done. Since trapped blisters do not use heat sealing, no expensive heat seal tooling is required. Typical constructions used for pharmaceutical products are 250 PVC film laminated to 15-150 PCTFE film. Typical WVTR values are 0.060.40 g/m2/day. Whilst this doesnt affect seal integrity, it does compromise pack aesthetics. Costco really loves stretch pak packaging. Face-seal blister packaging. For poor knurling, Delamination, hologram creasing on foil and; Faulty printing such as ink lining; ink patches and poor legibility of printed letters. Blister Packaging: What Is It? How Is It Made? Forming - IQS Directory The product is completely immobilized by the skin which gives added protection to the front of the card as well. Cyclic olefin copolymers (COC) or polymers (COP) can provide moisture barrier to blister packs, typically in multilayered combinations with polypropylene (PP), polyethylene (PE), or glycol-modified polyethylene terephthalate (PETg). Due to the COVID-19 pandemic, the global Blister Packaging Materials market size is estimated to be worth USD million in 2022 and is forecast to a readjusted size of USD million by 2028 with a . Increase your efficiency, reduce your costs, and quickly deliver your product to your customers. Form knurl wheels produce textured patterns by forming an impression. Knurling wheels, also known as a knurling die, are used to create a pattern or gripping surface on a cylindrical blank. Maximising the seal area. Your email address will not be published. Here is a comparison of a Face Seal Blister vs a Full Face Seal Blister. This entails TPI (the number of teeth per inch), the circular pitch (the distance between tooth to tooth), and the diametral pitch (the number of teeth per inch of workpiece diameter). This packaging is generally designed for the product to stand upright on store shelves or be hung using a standard die-cut hang hole. 0000009734 00000 n The PE (polyethylene) forms a soft intermediate layer between the rigid PVC and PVDC layers. I hope this gives you a basic idea of the different types of blister packaging as well as some popular blister alternatives. Bump Knurlers are used for holding knurl wheels to form a pattern or gripping surface on small- to medium-sized workpieces. For very deep draw thermoformed cavities, the triplex specifications are used: PVC/PE/PVDC, where the PE layer assists when forming deeper cavities. 0000007019 00000 n The consumer can visually examine the product through the transparent plastic. A fault in the machinery or format part might be the cause of it. Types of Blister Packaging - AIPAK In addition, the design of the upper sealing tool should activate the adhesive layer in the lidding material evenly by applying heat uniformly. It will not only create perfect knurl patterns but will also make sure there is no microchanneling because your sealing parts interlock perfectly. Feet to enable the clamshell to stand upright on store shelves and/or the addition of a hang hole can be easily included in this style of blister. Diamond Pattern Tip: Traversing is not recommended when using diamond knurls. Which makes regular maintenance of format parts important. Or like in Costco stores for example, standing upright in grooves inside tray boxes. For example, the handle of a hand tool can be knurled so that the hand does not slip off and a firm grip is maintained. If a high surface finish is required, knurl forming is the way to go. 252 0 obj <>stream The method most widely adopted by the pharmaceutical industry is the traditional blue dye test, due to its low cost and ease of implementation. Pro Pac distributes packaging materials and packaging machinery across the country. Blisters Knurling types and difference between them Blister packaging is a cost-effective way of showcasing a product. A series of blister cavities is sometimes called a blister card or blister strip as well as blister pack. Both have their limits and weaknesses. Depending on the way in which these variations are selected and applied, hundreds of unique approaches to knurling are possible. The information in this article is truly just scratching the surface of all there is to know about knurling operations. Another caveat is that micro channeling is not evident. They are designed to permit accurate tracking on standard fractional sized blanks. aH{pZ'sGr5dZq(zH5'9JL,X:0v13N`4} ( 6@ P?*o cq"G[J?w?PbFCS HUZW"*Z}lg>/u*R#:c(-W: y&T=]Z_E8.(USWf-L%`9wKE2\yh&M.|c^L9w?U:FlCP)vAWG'Ecys||k](P'mu$t775 Qs9vIt7{7N6S4xls O_LUq8AhL The European Pharmacopoeia (Ph Eur) references the requirements for PVC blister packs for pharmaceutical primary packaging in the monograph EP 3.1.11 "MATERIALS BASED ON NON-PLASTICISED POLY(VINYL CHLORIDE) FOR CONTAINERS FOR DRY DOSAGE FORMS FOR ORAL ADMINISTRATION". Ive been in the packaging industry for 15 years and if I can help you resolve a packaging dilemma, I will! Both of which are knurling processes achieved by pressing the knurl pattern into a round workpiece. They can be securely heat sealed, making them difficult to open by hand to deter tampering. [4] Trauma shears are also effective at opening packaging of this type. Tertiary packing: A Tertiary is used for bulk handling of drugs like storage in a warehouse. For different blister packaging, the blister, cavity, and box are different, as well as the shape, it will be different based on different products to be packed. In this type of packaging, the product is placed in deep-drawn pockets or cavities resembling a blister. High Speed Steel (HSS) provides good wear resistance and can be used in general-purpose applications for both ferrous and nonferrous materials. The blog details the following 8 blister sealing tips: Matching your packaging materials. WVTR values of commercial cyclic olefin-based pharmaceutical blister films typically range from 0.20 to 0.35 g/m2/day at 38C/90% RH. 0000008293 00000 n Products with high volumes do well with skin packaging. Both of which are knurling processes achieved by pressing the knurl pattern into a round workpiece. 2008 2023 Professional Packaging Systems, inc. These seven tips can help ensure a successful forming, filling, and sealing experience. In addition, sealing across a larger area and then cutting off the excess ensures there are no weak points. The principal advantage of cold form foil blisters is that the use of aluminum offers a near complete barrier for water and oxygen, allowing an extended product expiry date. The front card has a die cut hole for the blister shape to come through. It is crucial to choose wisely between hard-temper aluminum and soft-temper aluminum. Good luck! 0000001677 00000 n Robots handle sensitive parenteralia bags in pharma facility, PCR Content Popularity Gains on the Horizon. 0000015670 00000 n This is a multi-head knurling tool that features 6 separate wheels. 'Is an alu alu blister the best choice for your product? 0000001431 00000 n The most common lidding foil with push-through features is 20 hard tamper aluminum, which can be supplied pinhole-free from the producers. There are many types and variations of blister packs in use in the retail market. %PDF-1.4 % [5] Care must be used to safely open some of these packages, as opening it without care can result in injury; 6,000 Americans are sent to the emergency room each year by injuries suffered in opening such packages. Male diamond knurl wheels are used to create a female diamond knurl pattern. Due to the Tracking Correction Factor (C.F. Here youll find a practical approach designed to answer your questions about How to Buy Packaging! The seal is only on the flange while the rest of the card stays uncovered. Grizzly Industrial H7571 Floating Knurling Tool. 1 Like AsifHussain(Md.Asif Hussain) October 16, 2018, 5:30pm 2 Knurling in the blister help in proper sealing of the blister and proper knurling prevent blister from leak test failure.Proper Knurling shows good blister quality. 'Manual Blister Packing Machine, ideal for Small Batch Production'. Convex knurls have a sharp leading edge to spread out the loading. #PVC or polyvinyl chloride is the most common blister packaging material. We supply packaging equipment parts anywhere in the continental US. The warm plastic will then arrive in a forming station where a large pressure (4 to 8 bar) will form the blister cavity into a negative mold. 0000038261 00000 n The lidding film provides a peel-open feature and is generally porous to allow sterilization (such as the Dupont medical Tyvek material). Leaving the expiry or best before dates obsolete. For the pharma industry, blister packaging protects the medicines & products against: physical damage. They instead use plastic films that are more flexible and yet still very durable. The extra space will make up for extra space for heat to act and create an air-tight seal without micro channels. Pharmaceutical Blister Packaging Tooling Market - MarketWatch Brief Description of Blister Pack. 0000037880 00000 n Tooling costs for the heat seal can be expensive for these face seal blister packs, but a trapped blister (see below) doesnt require heat seal. %%EOF Knurls Technical Information | MSC Industrial Supply Co. Hello there if you are still looking for a blister packaging, try searching by the technical style and or the material you seek if known. Forming is ideal for shoulder diameter* knurling and for centerless workpieces. Unlike PVC and other common pharmaceutical barrier resins, cyclic olefin resins do not contain chlorine or other halogens in their molecular structure, being composed solely of carbon and hydrogen. Internal Knurlers are used for entering a workpiece radially. Thick steel plates that dont flex and bend coupled with rigid press assembly and geometry are design features that contribute to even distribution of force. [citation needed]. During Blister packing of solid oral dosage followings are the In-process checkpoints: Total number of packs to be tested= Number of cavities per track on the roller (for packwith 2 rows), Number of packs from each side = Total number/2 single row), Total number of packs to be tested = 2xNumber of cavities per track roller (for pack with 2 rows). If the workpiece material is on the harder side, cutting is your best bet. The most common types of blister packaging are as follows: Face seal blister The plastic blister is moulded around the product and heat-sealed to a cardboard backing. Ive seen this one a lot in retail stores. These methods can be based on melting and joining of sealant layers using heat sealing or on the application of a cold-seal adhesive coating to the inner surface of the packaging film.2Heat sealing is the most common method, which has been used for decades to shape and close the plastic packaging materials in the food industry. The thermoformed base web is made of a thicker plastic sheet, generally between 500 and 1000g and can not be collapsed, thus forming a solid tray. Sara has been in the packaging industry for over 15 years, not only on the design and manufacturing side, but also as a packaging buyer. Other types of blister packs consist of carded packaging where goods such as toys, hardware, and electrical items are contained between a specially made paperboard card and clear pre-formed plastic such as PVC. This has been a part of my tutorial series called How to Buy Packaging 101. Therefore, it cannot be easily duplicated. Thermoforming involves heating a sheet of plastic to a temperature where it can be easily formed and molded into any desired shape. . Determining Blank Diameter and the Number of Teeth that will be Rolled For Circular pitch knurls:Blank Dia. 0000016740 00000 n This film is very strong and clear and fits the product like an outer skin. PVDC blister films are available in 2 or 3 layer specifications referred to as duplex or triplex. It is measured along the wheel from one tooth point to the next. 0000026340 00000 n Circular pitch is based on the distance between the teeth per inch (TPI). However, the is a lesser perceived value from consumers on products with skin packaging, so a low price point for your product is important. Knurls have V-shaped teeth that deform, displace or push the material rather than cut it. biological contamination and degradation. [8], Polychlorotrifluoroethylene (PCTFE)[8] can be laminated to PVC to obtain very high moisture barrier. Duplex structures are PVC/PCTFE and triplex laminates are PVC/PE/PCTFE. 'Pharmaceutical Packaging: the silent bodyguard'. In other parts of the world, blister packs are the main packaging type since pharmacy dispensing and re-packaging are not common. This process displaces the material and increases the diameter of the workpiece. Left-hand diagonal knurl wheels are designed to produce right-hand diagonal patterns. There has to be at least 3millimeters of breathing space in the area between the inner lining that contains the product and the outer blister lining, including and paper lining for print and branding perforations on the lidding. From safety precautions to single or double wheel knurling and knurling best practices, you can dive much deeper and continue your knurling research, This post may contain affiliate links. Blister packaging is made using several types of rugged polymers, including: Polyethylene terephthalate (PET) Polyvinyl chloride (PVC) Polyvinylidene chloride (PVDC) + C.F.*). But as you will see here, regular blister packs are not as forgiving. Advertising space [ edit] There is a wide range of colors and finishes that blister packaging can be constructed to feature. Buy your blister sealer from us to get the production you need. aA.6 Z\ s7b(&@"M*iB}:Ih*0d*B5d4{Bbf&J( Glg$MYL There are a couple reasons for knurling. After the forming process a 250m film will have a final thickness of 50 to 100m in some deep drawn pockets. When the specimen of foil checked, packing shall start and initially packed medicine shall be checked for leak test. Choice of knurl pattern on the sealing tool plays a role in seal integrity too. There are several different types of blister packaging - Face Seal, Trap, Mock, Slide and Interactive. From clamps, scissors, wheels and machine tool inserts, knurling involves several different components, all of which have dozens of different options in terms of size, material, etc. 0000027906 00000 n Knurls have V-shaped teeth that deform, displace or push the material rather than cut it. The plastic shell is vacuum-formed around a mold so it can contain the item snugly. For this reason, there are many formulas that will help you to calculate the depth of cut, tracking pitch and cutting parameters in combination with the given material. Often a blister card is used (but doesnt have to be) and is inserted, not sealed as in the other styles of blister packs. Beveled edge wheels are best for forming operations. Intermittent platen sealing systems require higher pressure and longer sealing times, and tend to seal at a lower temperature because of these longer dwell times. The most common structures using the super barrier PVDC are triplex configurations 250 PVC/25 PE/120gsm PVDC up to 250 PVC/25 PE/180gsm PVDC, with WVTR of 0,11 down to 0,06 g/m2/day and available from various suppliers. One of the key pack design principles for ensuring a strong seal is to create the maximum seal area. A mock clamshell is a one piece blister where the blister card is sealed to the back of the blister.